Quizizz science collections

Student quizzing sites like Plickers and Quizizz are proving extremely useful for engagement and AfL this lockdown. One of the nice things about Quizizz is the volume of pre-made quizzes, but I usually find I want to tweak them for a few of reasons:

  1. I want to ensure my questions helpfully inform me about student understanding, not how good they are at picking obvious answers.
  2. I want a steady increase in difficulty. My general aim is that a class will achieve 70% accuracy in a quiz (an arbitrary threshold for not too difficult, not too easy). I want early recall questions to give the students a feeling of success in their knowledge, but I want the final questions to probe their understanding.
  3. I’ve found that running the same quiz at the beginning and end of a lesson helps the students see and enjoy their progress, but this approach definitely requires shorter quizzes than I was using originally.

Learning as I go along, my quiz collection more consistently applies the above three principles as it grows. Regardless, if you are interested in using Quizizz, I hope it will be a useful starting point:

MNicoll – Quizizz Collections

Science misconceptions bank

This post provides a permanent link to two work-in-progress documents listing student misconceptions in biology, chemistry and physics. Both are collations of previously-published information (citations in each) and personal experience.

I plan to periodically update these links with the most current versions, but they should be useful as-is.

Constellations and common sense

In the vein of making videos about interesting stuff I come across, the other day I stumbled across the story behind these five dots:

EURion constellation
From: https://commons.m.wikimedia.org/wiki/File:EURion.svg#mw-jump-to-license

Not much to look at – but! – these dots, which are known as the EURion constellation, are interesting because if they exist on a piece of paper you’d like to scan or photocopy, the machine will refuse to copy the paper.

This is useful for two things:

  • Pranks
  • Preventing the copying of banknotes for money counterfeiting

In fact, the EURion constellation is very popular on banknotes! Here is a happy citizen, gazing with love at a shiny new £10 UK note, and sure enough, there’s a bunch of orange EURion dots on the left of the note:

JPEG image
From https://www.flickr.com/photos/bankofengland/35809801882/in/album-72157662787666013/

I guess I’m pretty naive about how money is designed. Unless it’s something like the Euro 1, I assumed that every country designed everything that went on to their banknotes. Wrong – because the EURion constellation crops up on a few other notes.

From the Wikipedia, these include the Armenian dram, Aruban florin, Austrian schilling, Australian dollar, Belgian franc, Bosnia and Herzegovina convertible mark, Bulgarian lev, Canadian dollar, CFA franc, Chilean peso, Chinese yuan, Comorian franc, Croatian kuna, Czech koruna, Danish krone, Djiboutian franc, Dutch guilder, Egyptian pound, Euro, Faroese króna, French franc, German mark, Hungarian forint, Indian rupee, Indonesian rupiah, Japanese yen, Kyrgyzstani som, Kuwaiti dinar, Macanese pataca, Malagasy ariary, Mexican peso, Moroccan dirham, Namibian dollar, Netherlands Antillean gulden, Norwegian krone, Polish złoty, Romanian leu, Saudi riyal, Singapore dollar, South African rand, South Korean won, Slovak koruna, Surinamese dollar, Swazi lilangeni, Swedish krona, Swiss franc, Thai baht, Tunisian dinar, Turkish lira, Ugandan shilling, United Arab Emirates dirham, United States dollar and Zimbabwean bond notes.


So why am I not making a video about this? Weeeeeell, here’s the common sense.

What I wanted to do was make a video in which I would essentially have a slideshow of bank notes, zooming in to the constellations and highlighting five dots, possibly to the beat of something like Take Five, for any watching music nerds.

This would be cool because a) I could show you just how widespread this semi-secret symbol is, b) how some countries nicely use the constellation in their design, rather than the obvious “here are some dots” approach on the current UK notes, and c) it’d probably be more engaging than something like, say, a blog post.

The thing is – as I’d been thinking about, at length – governments across the world do not want you to make digital copies their notes.

They would like it if you didn’t include all, or even parts of, their notes in your projects. They even used things like, oh I don’t know, the EURion constellation to help to prevent people spreading pictures of banknotes.

The Bank of England has a whole page dedicated to the digital use of their notes, as well as a handy list of approved images which you can use without going to prison. You can also contact various countries’ banks asking for permission, but… that was never going to happen.

So in future, before embarking on a project, collecting the highest resolution images of as many of the world’s banknotes as I can find, scoping out free-use music in 5/4 timing and typing “counterfeiting banknotes” into Google enough times to get added to a watchlist, I will try to ask myself “is there any reason I shouldn’t make this?”.

  1. From which the EURion constellation gets its name: a) because it looks a bit like the Orion constellation and b) because it was discovered on Euros – that’s right – discovered. This anti-fraud device was invented, quietly rolled out across the world and it seems like we only know about them because somebody noticed. ↩︎

Link to go viral 11/04/15 – HIV spreads like internet malware and should be treated earlier

HIV spreads like internet malware and should be treated earlier – UCL News – Published on: 2 Apr 2015

The reason we call nasty computer programmes ‘viruses’ is because their behaviour mimics the real thing – spread between individuals, make more copies of yourself and repeat. So it’s kind of glorious that we can flip this around and learn about the viruses that make us sick by studying their digital analogues.

Here a team from London, Oxford and Changsha (in China) looked at the role of ‘hybrid spreading’ – a phenomenon shared by HIV infection and computer malware such as the Conficker worm. These viruses both spread over long-distances (bloodstream / the internet) and between close contacts (between cells / between computers on a local network). And both are also extremely difficult to get rid of once the infection is fully established because local ‘pockets’ of virus can be difficult to eliminate1.

The computer model the research team have developed suggests that to combat HIV infection in people, we need treatments that work effectively against both means of spread, and we need to treat earlier than we currently do. The team’s model may also provide a way of testing whether drugs are effective at stopping cell-to-cell spread; a measurement that is otherwise difficult to study.

  1. Retroviruses such as HIV may also be impossible to completely eliminate, as these guys can hang out in cell DNA, where such drug treatments can’t reach them.

An audacious DARPA plan to arm your cells against Ebola

During an infection, the cellular ranks of our immune system army fall into two different squads: Rhinos and Elephants. While the Rhinos’ orders are to charge headlong at the invader (on the double!), the Elephants have a more subtle objective: remember this enemy.

If you win the battle against the maraudering microbe, the brave and knackered fighters of Rhino squad are rewarded with “early retirement”1, but the Elephants (actually called ‘Memory Cells’) live on and await a repeat encounter with the enemy. Should the bug come back, the memory cells rapidly turn Rhino and destroy the germ before it can so much as dig a trench.

When we vaccinate ourselves against an infection, what we’re trying to do is build up a squad of germ-specific memory cells without having to go through the pain of getting the disease the first time around. This is a miraculous medical tool – just look at the number of infections per year in the US before and after vaccines.

The problem with vaccines is that they are difficult2 and time-consuming to develop. When a brand new virus species causes an outbreak in the future, we will need another strategy to stop its spread in the short-term: vaccines are for old foes, not the new disease on the block.

But an interesting project underway at the Defense Advance Research Projects Agency (DARPA) is aiming to give us rapid vaccine-like powers by transferring the immunological memory from a single person to everybody else.

To understand how it works we have to return to the memory cell squad of our army. Just like a regular army, the memory cells comprise separate units which attack at short or long-range. It is the long-range attackers, called B-cells, that are the focus of the DARPA project.

B-cells wage war by releasing sticky chemicals that plaster themselves on to specific microbes. When smothered in these chemicals the germ is prevented from going about its business and is painted as a target for destruction. If the chemical, called an antibody, sticks strongly to the right spot on the germ: hasta la vista, buggy.

Each of our B-cells is stuck in their way. When they’re growing up, they rearrange their DNA to try to make antibodies that stick better to incoming germs, and only those that succeed get the job. As the successful will only ever make one version of an antibody, we can look at the cell’s DNA, find the antibody’s genetic code and make it in the lab – no B-cell required. And this is where the DARPA project comes in.

As described in a story published on the website Fusion.net, the idea is to recover B-cells from survivors of disease (for example, people recovering from Ebola) and learn the genetic code for the best antibodies targetting the infection.

So far, so good. But the next step? Inject DNA containing the antibody code into the blood of uninfected people, where it will be taken up by cells in their body, decoded and used to start pumping out the antibody. Should these people then catch the disease, the bug doesn’t just have to worry about the regiments of the immune system, it has to worry about the armed civilian populace.

This plan is audacious, and there are plenty of reasons to be skeptical about its success. Even if you get to the stage where your cells are happily pumping out the antibodies, viruses can throw up a number of problems:

  • they could mutate; changing shape so the antibody doesn’t bind any more
  • if they spread directly between cells rather than being released out into the open spaces of your body, antibodies won’t have a chance to bind them (HIV and herpesviruses, for example)
  • they may already have countermeasures against antibodies (again, herpesviruses)

But even if the plan didn’t work against everything, that doesn’t mean it won’t against any. And if it does work? That would be incredible.

Head over to Fusion for the full story, including much more on the technology of vaccination using DNA and the hurdles standing in the way of the technique’s progress.

Linked article: DARPA thinks it has a solution to Ebola (and all other infectious diseases) – Fusion – Published on: 18 Mar 2015

  1. i.e. they all get told to commit suicide – a pumped-up army with nothing to shoot at is potentially dangerous for those left standing (that’s you, by the way).
  2. I covered (one of) the problems with testing Ebola vaccines in this article, but note, unlike my prediction from the data at the time, Ebola unfortunately remains live and well in West Africa.

Links to go viral – 16th March 2015

A day late, but a link longer. Here’s this week’s lovely links:

A live look at the AIDS virus – Science Magazine

So cool. Being able to image where a virus is hiding inside an infected animal or person is a big sci-fi-esque deal. Current bioluminescence imaging techniques, where the glowy-glowy genes of fireflies are engineered into viruses, are an excellent tool for studying virus spread in small animal models of infection. But what if you’re an AIDS researcher relying on larger animal stand-ins to study human disease? In this work, the authors used a system called immunoPET to see where simian immunodeficiency virus (SIV – a simian contemporary of the human virus, HIV) collected and spread inside live macaques. The system works by injecting SIV-specific antibodies into the macaques, which then lock on to the virus particles and stick to them. Cunningly attached to these antibodies are radioactive molecules that can be detected using a PET scanner (PET stands for Positron Emission Tomography, and is a fascinating medical tool). Thus, via the interface of antibodies, virology and PET combine to visualise the location and amount of virus deep inside the body. The work revealed unknown reservoirs of virus infection in the upper respiratory tract and could potentially act as an avenue for studying infection in people, though I’d guess that was some way off. Click through to see some great images of the work and more discussion.

Countries Reeling From Ebola Are Facing A Big Measles Threat – Buzzfeed News

Simply put: the current Ebola-afflicted countries had gotten complacent about Measles vaccination, had realised this and aimed to roll out large-scale vaccination campaigns – and then Ebola hit and ruined everything. The successful vaccination coverage in these countries is now way below where it should be. It’s also important to note that the same is true of other diseases. Western Africa would usually have a full anti-malaria campaign in action, but Ebola has wrecked the pre-existing healthcare infrastructure.

As an aside, this isn’t the first interesting science article I’ve read from Buzzfeed recently. Who knew it wasn’t just about the cats, lists and lists of cats?

Ebola survivors offer clues to body’s virus defences – Nature News

A small study has shed some light on the immune response to Ebola infection. The immune responses of four people treated at Emory University Hospital were assessed to understand how the human body combats the virus. Interestingly, the patients had strong T-cell responses to the virus nucleoprotein, which wraps up the virus genome. As our current vaccine attempts are targetted at driving an antibody response to the virus surface glycoprotein, this new information could help us develop a superior treatment against the virus. The big caveat to note is that these infected individuals received novel anti-viral treatment that could have interfered with the normal development of the immune response, and (of course) the sample size here is just four people.

‘Disease is no longer a problem’ claims deadly bacteria – The Guardian

All this talk about stopping Ebola, but has nobody asked the virus what it thinks? No: it’s just another form of discrimination. Whilst this is 99% political parody rather than microbiology, I couldn’t resist – a great article where pox virus stands in for a pox on the UK political landscape. Perfect.

Links to go viral – 8th March 2015

This week, viruses take to the air (via creatures with wings) and a chat about herpesviruses:

Study: “Wild bumblebees vulnerable to variety of viruses” – UPI

Honeybees toil endlessly to make delicious delicious honey, but just like you and me, they have their off days when they don’t feel the buzz. Mites, microrganisms and viruses are enough to put pupa off their pollen, and a sick hive can suffer reduced honey production to full colony collapse. With our vested interest in their well-being, we’ve swotted up on what blights our bees, but whether the unwelcome critters in our managed hives reflect those that bug bumblebees in the wild is less understood. Things I learned from the linked article: 1) there’s some spillover of viruses from our own workers to wild bee populations, with transmission possibly occurring from sharing the same flowers, 2) bee viruses have excellent names – black queen cell virus, deformed wing virus, acute bee paralysis virus, slow bee paralysis virus and sacbrood virus.

Wild birds may spread flu virus – BBC News

If our bees are propagating viruses that later swarm into the wild, birds provide the opposite flight path when it comes to flu.

I think the headline “Wild birds may spread flu virus” is kind of like saying “water flows downhill”, but the article itself is a useful look into how the H5N8 and H7N7 bird flu viruses are travelling around Europe. For instance, ducks on a farm in Yorkshire in the UK may have contracted H5N8 from migratory birds from Russia. How this happens isn’t clear yet, as poultry are kept inside and wouldn’t have mixed with the wild birds.

Peter O’Hare & herpesviruses – meet the expert – CVR Blog

The guys at the University of Glasgow Centre for Virus Research interview herpesvirologist Professor Peter O’Hare. A great overview of the some of the history, problems and questions associated with those ‘creeping’ viruses of humans. Whilst Peter’s lab do some cool work (this one is a recent favourite – Open Access), he doesn’t include virus latency in his list of big questions in herpesvirology! 😦 For the sake of my fragile little feelings, I’ll assume this is because we’re answering some of the questions, rather than it not being interesting…